Association Between Excessive Urinary Iodine Excretion and Failure of Radioactive Iodine Thyroid Ablation in Patients with Papillary Thyroid Cancer

• DOI: 10.1089/thy.2012.0136
• Publication Date: 2012-12-04T20:18:16Z
• Authors: Seo Young Sohn; Joon Young Choi; Hye Won Jang; Hye Jeong Kim; Sang Man Jin; Se Won Kim; Sunghwan Suh; Kyu Yeon Hur; Jae Hyeon Kim; Jae Hoon Chung; Sun Wook Kim
• Keywords: Thyroglobulin

Background: A low-iodine diet (LID) is usually recommended for a week or two before radioactive iodine (RAI) ablation therapy in papillary thyroid cancer (PTC) patients after total thyroidectomy. However, it still controversial whether an LID affects outcomes. We therefore evaluated the association between urinary excretion and rate of successful investigated determinants RAI Methods: retrospectively reviewed records 295 consecutive with PTC who received 1110 MBq remnant hormone withdrawal Successful was defined as either no visible faint uptake on follow-up scan (definition 1), stimulated thyroglobulin level <2 ng/mL 2). Results: The proportion appropriate status (defined concentration [UIC] <66.2 μg iodine/g creatinine [μg/gCr]) significantly higher successfully ablated group (81% vs. 67%, p=0.03). Based definition 1, 80.3% (237/295) were ablated. lower had UIC >250 μg/gCr at time (p<0.05). In multivariate analysis, only significant variable associated failure (p=0.002, odds ratio [OR] 4.74 [95% confidence interval (CI) 1.78–12.63]). 2, 74.9% (221/295) administration showed OR 3.88 [CI 1.42–10.57] (p=0.008). Conclusion: Excessive intake (UIC μg/gCr) poor Because this amount very high, we propose that strictness protocol should be modified according to region patient from food accustomed eating. Even those areas where overly strict compliance not necessary simple recommendations avoid iodine-rich foods would appropriate.