Variation in Normal Range Thyroid Function Affects Serum Cholesterol Levels, Blood Pressure, and Type 2 Diabetes Risk: A Mendelian Randomization Study

• DOI: 10.1089/thy.2020.0393
• Publication Date: 2020-08-04T08:21:38Z
• Authors: Aleksander Kuś; Eirini Marouli; Fabiola Del Greco M.; Layal Chaker; Tomasz Bednarczuk; Robin P. Peeters; Alexander Teumer; Marco Medici; Panos Deloukas
• Keywords: Mendelian Randomization; Dyslipidemia

Observational studies have demonstrated that variation in normal range thyroid function is associated with major cardiovascular risk factors, including dyslipidemia, hypertension, type 2 diabetes (T2D), and obesity. As observational are prone to residual confounding, reverse causality, selection bias, we used a Mendelian randomization (MR) approach investigate whether these associations causal or not.