Two glucose sensing/signaling pathways stimulate glucose-induced inactivation of maltose permease in Saccharomyces.

• DOI: 10.1091/mbc.8.7.1293
• Publication Date: 2013-08-16T19:21:19Z
• Authors: H Jiang; I Medintz; C A Michels
• Keywords: Snf3; Metabolic pathway

Glucose is a global metabolic regulator in Saccharomyces. It controls the expression of many genes involved carbohydrate utilization at level transcription, and it induces inactivation several enzymes by posttranslational mechanism. SNF3, RGT2, GRR1 RGT1 are known to be glucose regulation transcription. We tested roles these glucose-induced maltose permease. Our results suggest that least two signaling pathways used monitor levels. One pathway requires sensor transcript second independent transport. Rgt2p, which along with Snf3p monitors extracellular levels, appears for glucose-transport-independent pathway. Transmission Rgt2p-dependent signal Grr1p. RGT2 also play role regulating HXT genes, appear upstream components glucose-transport-dependent permease inactivation. RGT2-1, was identified as dominant mutation causing constitutive causes proteolysis permease, is, absence glucose. A model sensing/signaling presented.