Relation of cigarette smoking and alcohol drinking in midlife with risk of cognitive impairment in late life: the Singapore Chinese Health Study

• DOI: 10.1093/ageing/afy166
• Publication Date: 2018-10-02T19:10:04Z
• Authors: Jing Wu; Wenhong Dong; Xiong-Fei Pan; Lei Feng; Jian-Min Yuan; An Pan; Woon-Puay Koh
• Keywords: Aged, 80 and over; Male; China; Singapore; Alcohol Drinking; Smoking; Age Factors; Middle Aged; Mental Status and Dementia Tests; 16. Peace & justice; 3. Good health; 03 medical and health sciences; Logistic Models; 0302 clinical medicine; Risk Factors; Confidence Intervals; Odds Ratio; Humans; Cognitive Dysfunction; Female; Aged

the relations of cigarette smoking and alcohol drinking with risk cognitive impairment remain inconsistent. to examine independent joint impairment, we used data from 16,948 men women, who had been followed-up for 16–23 (mean 20) years as participants Singapore Chinese Health Study, a population-based prospective cohort. Data on were collected at baseline (1993–98), when aged 45–74 53) years. Cognition was assessed using 30-item Mini-Mental State Examination during follow-up three visits (2014–16), 61–96 73) Multivariable logistic regression models estimate odd ratios (ORs) 95% confidence intervals (CIs). present in 2,443 (14.4%) participants. Compared non-current smokers, current smokers 20% increased (OR = 1.20, CI 1.04–1.39). those drank less than weekly, regular (at least weekly) 17% 1.17, 1.01–1.36). neither nor drinkers, either or drinkers alone no significantly risk, while highest both 1.77, 1.39–2.26, Pinteraction 0.003). co-existence midlife much stronger impact individual factors late life.