Severe acute malnutrition in childhood, chronic diseases, and human capital in adulthood in the Democratic Republic of Congo: the Lwiro Cohort Study

• DOI: 10.1093/ajcn/nqab034
• Publication Date: 2021-02-03T04:40:19Z
• Authors: Pacifique Mwene-Batu; Ghislain Bisimwa; Gaylord Ngaboyeka; Michèle Dramaix; Jean Macq; Michel P Hermans; Daniel Lemogoum; Philippe Donnen
• Keywords: Adult; Male; Adolescent; Medicine (miscellaneous); Child Nutrition Disorders; chronic diseases; Cohort Studies; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Long-term; follow-up; Humans; Child; Noncommunicable Diseases; 2. Zero hunger; childhood acute malnutrition; long-term; Nutrition and Dietetics; Follow-up; Severe Acute Malnutrition; Childhood acute malnutrition; 1. No poverty; Sciences bio-médicales et agricoles; 16. Peace & justice; 3. Good health; Original Research Communications; Chronic diseases; Chronic Disease; Democratic Republic of the Congo; Female; DR Congo

Little is known about the long-term outcome of children treated for severe acute malnutrition (SAM) after nutritional rehabilitation. To explore association between SAM in childhood, noncommunicable diseases (NCDs), and low human capital adulthood. We identified 524 adults (median age: 22 y) who were during childhood Eastern Democratic Republic Congo 1988 2007. They compared with 407 community unexposed age- sex-matched subjects no history SAM. The variables interest cardiometabolic risk markers NCDs capital. For comparison, we used linear logistic regressions to estimate ordinal regression Compared subjects, exposed participants had a higher waist circumference [1.2 (0.02, 2.3) cm; P = 0.015], larger waist-to-height ratio [0.01 (0.01, 0.02) < 0.001]. On other hand, they smaller hip [-1.5 (-2.6, -0.5) 0.021]. Regarding NCDs, apart from glycated hemoglobin (HbA1c) [0.4 (0.2, 0.6); 0.001], difference was observed NCD 2 groups. participants, metabolic syndrome (crude OR: 2.35; 95% CI: 1.22, 4.54; 0.010) visceral obesity [adjusted 1.44 (1.09, 1.89); prevalence hypertension, diabetes, overweight, dyslipidaemia similar both Last, proportion survivors socioeconomic status level lower. associated high lower Thus, policymakers funders seeking fight global spread low-resource settings should consider benefit reducing as preventive measure reduce burden attributable NCDs.