A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

• DOI: 10.1093/ajcn/nqab045
• Publication Date: 2021-02-23T20:16:06Z
• Authors: Joanna L Clasen; Alicia K Heath; Heleen Van Puyvelde; Inge Huybrechts; Jin Young Park; Pietro Ferrari; Mattias Johansson; Ghislaine Scelo; Arve Ulvik; Øivind Midttun; Per Magne Ueland; Christina C Dahm; Jytte Halkjær; Anja Olsen; Theron Johnson; Verena Katzke; Matthias B Schulze; Giovanna Masala; Francesco Segrado; Maria Santucci de...; Carlotta Sacerdote; Marga C Ocké; Leila Luján-Barroso; Ana Ching-López; José María Huerta; Eva Ardanaz; Pilar Amiano; Ulrika Ericson; Jonas Manjer; Björn Gylling; Ingegerd Johansson; Julie Schmidt; Elisabete Weiderpass; Elio Riboli; Amanda J Cross; David C Muller
• Keywords: Male; 0301 basic medicine; Vitamines; dietary biomarkers; Medicine (miscellaneous); dietary biomarker; HOMOCYSTEINE; PLASMA PYRIDOXAL 5'-PHOSPHATE; vitamin B6; 09 Engineering; SERUM; DIETARY-INTAKE; Neoplasms; Medicine and Health Sciences; AMINO-ACIDS; Càncer; ONE-CARBON METABOLISM; 11 Medical and Health Sciences; Cancer; 2. Zero hunger; Nutrition and Dietetics; SOLUBLE VITAMINS; Factors de risc en les malalties; Biochemical markers; Estudios de Casos y Controles; Vitamins; Middle Aged; Neoplasias; 3. Good health; Europe; MICROBIOLOGICAL ASSAY; Original Research Communications; Marcadors bioquímics; Female; Vitamin B 6 Deficiency; Life Sciences & Biomedicine; kynurenine pathway; Risk factors in diseases; Vitamin B 6/blood; BIOMARKERS; 610; Nutritional Status; PLP; 03 medical and health sciences; Humans; transsulfuration pathway; Aged; Cancer och onkologi; Science & Technology; Nutrition & Dietetics; Vitamin B 6; Cancer and Oncology; Case-Control Studies; Linear Models; B-VITAMINS; Vitamina B 6; Neoplasms/epidemiology

Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration pyridoxal 5′-phosphate (PLP) is a commonly used measure vitamin status. Ratios substrates indicating PLP coenzymatic function metabolism may be useful complementary measures further explore the role in health. We explored sensitivity 5 outcomes, namely concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), 3´-hydroxykynurenine ratio (HKr), 4-pyridoxic acid (PAr) intake as well personal lifestyle characteristics. Dietary biomarker data were collected from participants 3 nested case-control studies within European Prospective Investigation into Cancer Nutrition (EPIC). Bayesian regression models assessed associations outcomes with covariates. Analogous examined relations Hcy:Cys, Cysta:Cys, HKr PLP. In total, 4608 included analyses. was most strongly associated PLP, moderately HKr, not PAr (fold change marker given doubling intake: 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 CrI: 0.84, 0.90]; Cysta:Cys 0.89 0.94]; 0.88 0.85, 0.91]; 1.00 0.95, 1.05]). sensitive age, least BMI alcohol intake. Sex menopause status all markers. found that different markers, capturing aspects B6–related biological processes, varied their predictors.