Primary Central Nervous System Lymphomas in 72 Immunocompetent Patients: Pathologic Findings and Clinical Correlations

• DOI: 10.1093/ajcp/110.5.607
• Publication Date: 2016-03-17T02:30:18Z
• Authors: Sophie Camilleri-...; Antoine Martin; Anne Moreau; Régis Angonin; Dominique Hénin; Marie Francine Go...; Marie Christine R...; Sylvie Caulet-Mau...; Paulette Cuillière; Thierry Lefrancq; Karima Mokhtari; Mohib Morcos; Philippe Broët; Michèle Kujas; Jean-Jacques Hauw; Bernard Desablens; Martine Raphaël
• Keywords: Immunophenotyping

We reviewed 72 primary central nervous system lymphomas occurring in immunocompetent patients. The cases were for clinical data, histology, immunophenotype, bcl-2 and p53 expression, Epstein-Barr virus association. Follow-up was available 40 patients included the Groupe Ouest Est d'étude des Leucénies et Autres Maladies du Sang (GOELAMS) lymphomes cérébraux primitifs (LCP 88) trial. Each diagnosis, requiring a consensus among at least 3 pathologists, performed according to recent Revised European-American Lymphoma classification equivalents updated Kiel classification. Tumors predominantly classified as diffuse large B-cell lymphomas. There T-cell 1 Hodgkin lymphoma. proteins expressed 35% 16% of tested cases, respectively. not found by situ hybridization except case classfied cerebral localization disease. No significant association between subtypes, or patient survival. From standpoint their biologic characteristics, are very similar systemic In contrast AIDS-related lymphomas, rarely associated with they express relatively low rate.