Leptin Expression and Gene Methylation Patterns in Alcohol-Dependent Patients with Ethyltoxic Cirrhosis—Normalization After Liver Transplantation and Implications for Future Research

• DOI: 10.1093/alcalc/agy038
• Publication Date: 2018-05-12T19:08:17Z
• Authors: P J Proskynitopoulos; M Rhein; E Jäckel; M P Manns; H Frieling; S Bleich; T Thum; T Hillemacher; A Glahn
• Keywords: Liver disease

Liver transplantation is the only curative treatment available for patients with end-stage alcoholic liver disease. As different studies showed a significant association between leptin plasma levels, gene methylation patterns and extent of craving in alcohol-dependent patients, we investigated effect on expression promoter methylation.The present study shows that cirrhosis significantly higher before decreases after transplantation. Alcohol-dependent waiting list had values than who underwent other reasons disease.Only 118 peripheral blood mononuclear cells 121 were used: healthy controls (C, n = 24/22), without ethyltoxic (AD, (C-Tx, 18/21), suffering from (Pre-Tx, 30/28) prior (Post-Tx, 22/28).Leptin protein was elevated pre-transplantation cohort when compared to post-transplantation cohorts. Furthermore, non-ethyltoxic transplantation, but not C-Tx lower all groups except Post-Tx.Our outlines role levels as marker AD-related damage, contrasting it AD severe damage. With regard results analysis, inflammation appears cause mechanisms regulation deviate transcriptional regulation. Our data also suggest altered disease caused by pathologies.