methylclock: a Bioconductor package to estimate DNA methylation age

• DOI: 10.1093/bioinformatics/btaa825
• Publication Date: 2020-09-08T11:11:23Z
• Authors: Dolors Pelegí-Sisó; Paula de Prado; Justiina Ronkainen; Mariona Bustamante; Juan R González
• Keywords: dNaM; Bioconductor

Ageing is a biological and psychosocial process related to diseases mortality. It correlates with changes in DNA methylation (DNAm) all human tissues. Therefore, epigenetic markers can be used estimate age using DNAm profiling across tissues.We developed Bioconductor package that allows computation of several existing adult/childhood gestational clocks. Functions visualize the prediction versus chronological correlation between clocks are also available as well other features, such missing data imputation cell types' estimates, required for clocks.https://github.com/isglobal-brge/methylclock.Supplementary at Bioinformatics online.