grenedalf: population genetic statistics for the next generation of pool sequencing

• DOI: 10.1093/bioinformatics/btae508
• Publication Date: 2024-08-25T01:26:21Z
• Authors: Lucas Czech; Jeffrey P Spence; Moisés Expósito-A...
• Keywords: Summary statistics

Abstract Summary Pool sequencing is an efficient method for capturing genome-wide allele frequencies from multiple individuals, with broad applications such as studying adaptation in Evolve-and-Resequence experiments, monitoring of genetic diversity wild populations, and genotype-to-phenotype mapping. Here, we present grenedalf, a command line tool written C++ that implements common population statistics θ, Tajima’s D, FST sequencing. It orders magnitude faster than current tools, focused on providing usability scalability, while also offering plethora input file formats convenience options. Availability implementation grenedalf published under the GPL-3, freely available at github.com/lczech/grenedalf.