COPS Benchmark: interactive analysis of database search methods

• DOI: 10.1093/bioinformatics/btp712
• Publication Date: 2010-01-16T01:14:00Z
• Authors: Karl Frank; Markus Gruber; Manfred J. Sippl
• Keywords: Benchmark (surveying)

Abstract Summary: The performance of sequence database search methods is usually judged by receiver operating characteristic (ROC) analysis. proper interpretation the results obtained and a fair comparison across different critically depends on properties data set used for such an analysis; in particular, each query must have same number true positives negatives. Here, we present novel web service based dataset specifically designed ROC analysis investigation alignment quality. derived from quantitative classification protein structures (COPS), while are presented through intuitive interface. provides details as false per query, visualization structural similarity between targets. Most importantly, specific method immediately related to those several popular standard methods. Availability: COPS-Benchmark available at http://benchmark.services.came.sbg.ac.at Contact: [e-mail]