ChromoHub: a data hub for navigators of chromatin-mediated signalling

• DOI: 10.1093/bioinformatics/bts340
• Publication Date: 2012-06-23T08:09:48Z
• Authors: Lihua Liu; Xi Ting Zhen; Emily Denton; Brian D. Marsden; Matthieu Schapira
• Keywords: Relevance; Signalling

Abstract Summary: The rapidly increasing research activity focused on chromatin-mediated regulation of epigenetic mechanisms is generating waves data writers, readers and erasers the histone code, such as protein methyltransferases, bromodomains or deacetylases. To make these easily accessible to communities scientists coming from diverse horizons, we have created ChromoHub, an online resource where users can map phylogenetic trees disease associations, structures, chemical inhibitors, substrates, chromosomal aberrations other types extracted public repositories published literature. interface be used define structural coverage a family, highlight domain architectures, interrogate relevance zoom in specific genes for more detailed information. This open-access should serve hub cell biologists, medicinal chemists, biologists navigators that explore biology chromatin signalling. Availability: http://www.thesgc.org/chromohub/. Contact: [e-mail] Supplementary Information: are available at Bioinformatics online.