ComplexViewer: visualization of curated macromolecular complexes

• DOI: 10.1093/bioinformatics/btx497
• Publication Date: 2017-08-01T11:19:46Z
• Authors: Colin W Combe; Marine (Dumoussea...; Henning Hermjakob; Joshua Heimbach; Birgit H M Meldal; Gos Micklem; Sandra Orchard; Juri Rappsilber
• Keywords: 0303 health sciences; 03 medical and health sciences; Macromolecular Substances; Computational Biology; Protein Interaction Domains and Motifs; Protein Interaction Maps; Applications Notes; Models, Biological; Software; Protein Binding

Abstract

Summary Proteins frequently function as parts of complexes, assemblages of multiple proteins and other biomolecules, yet network visualizations usually only show proteins as parts of binary interactions. ComplexViewer visualizes interactions with more than two participants and thereby avoids the need to first expand these into multiple binary interactions. Furthermore, if binding regions between molecules are known then these can be displayed in the context of the larger complex.

Availability and implementation freely available under Apache version 2 license; EMBL-EBI Complex Portal: http://www.ebi.ac.uk/complexportal; Source code: https://github.com/MICommunity/ComplexViewer; Package: https://www.npmjs.com/package/complexviewer; http://biojs.io/d/complexviewer. Language: JavaScript; Web technology: Scalable Vector Graphics; Libraries: D3.js.