STAR Chimeric Post for rapid detection of circular RNA and fusion transcripts

• DOI: 10.1093/bioinformatics/bty091
• Publication Date: 2018-02-17T04:10:48Z
• Authors: Nicholas K Akers; Eric E Schadt; Bojan Losic
• Keywords: Circular RNA

The biological relevance of chimeric RNA alignments is now well established. Chimera arising as chromosomal fusions are often drivers cancer and recently discovered circular (circRNA) only being characterized. While software already exists for fusion discovery quantitation, high false positive rates run-times hamper scalable on large datasets. Furthermore, available circRNA detection quantification limited.Here, we present STAR Chimeric Post (STARChip), a novel package that processes from the aligner produces annotated precision in rapid, efficient manner appropriate dimensional medical omics datasets.STARChip at https://github.com/LosicLab/STARChip.Supplementary data Bioinformatics online.