SanXoT: a modular and versatile package for the quantitative analysis of high-throughput proteomics experiments

• DOI: 10.1093/bioinformatics/bty815
• Publication Date: 2018-09-24T19:13:19Z
• Authors: Marco Trevisan-He...; Navratan Bagwan; Fernando García-M...; Jose Manuel Rodri...; Inmaculada Jorge; Iakes Ezkurdia; Elena Bonzon-Kuli...; Jesús Vázquez
• Keywords: Proteomics; 0301 basic medicine; 03 medical and health sciences; Proteins; Peptides; Applications Notes; Mass Spectrometry; Software

Abstract

Summary Mass spectrometry-based proteomics has had a formidable development in recent years, increasing the amount of data handled and the complexity of the statistical resources needed. Here we present SanXoT, an open-source, standalone software package for the statistical analysis of high-throughput, quantitative proteomics experiments. SanXoT is based on our previously developed weighted spectrum, peptide and protein statistical model and has been specifically designed to be modular, scalable and user-configurable. SanXoT allows limitless workflows that adapt to most experimental setups, including quantitative protein analysis in multiple experiments, systems biology, quantification of post-translational modifications and comparison and merging of experimental data from technical or biological replicates.

Availability and implementation Download links for the SanXoT Software Package, source code and documentation are available at https://wikis.cnic.es/proteomica/index.php/SSP.

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Supplementary information Supplementary information is available at Bioinformatics online.