simuG: a general-purpose genome simulator

• DOI: 10.1093/bioinformatics/btz424
• Publication Date: 2019-05-18T11:09:07Z
• Authors: Jia-Xing Yue; Gianni Liti
• Keywords: 0301 basic medicine; [SDV.GEN]Life Sciences [q-bio]/Genetics; Genome; [SDV]Life Sciences [q-bio]; 0206 medical engineering; [SDV.GEN] Life Sciences [q-bio]/Genetics; Genomics; 02 engineering and technology; Applications Notes; Polymorphism, Single Nucleotide; [SDV] Life Sciences [q-bio]; 03 medical and health sciences; Humans; Software

Abstract Summary Simulated genomes with pre-defined and random genomic variants can be very useful for benchmarking bioinformatics analyses. Here we introduce simuG, a lightweight tool simulating the full-spectrum of (single nucleotide polymorphisms, Insertions/Deletions, copy number variants, inversions translocations) any organisms (including human). The simplicity versatility simuG make it unique general-purpose genome simulator wide-range simulation-based applications. Availability implementation Code in Perl along user manual testing data is available at https://github.com/yjx1217/simuG. This software free use under MIT license. Supplementary information are Bioinformatics online.