PIVKA-II as a biomarker in pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency: implications for vitamin K therapy

• DOI: 10.1093/bjd/ljaf078
• Publication Date: 2025-03-04T21:22:33Z
• Authors: Suzuka Miyamoto; Satoru Shinkuma; Koji Yada; Kengo Hamada; Kohei Ogawa; Keiji Nogami; Hideo Asada

This manuscript presents a detailed case study of familial instances of pseudoxanthoma elasticum (PXE)-like syndrome, focusing on the elevation of protein induced by vitamin K absence or antagonist (PIVKA)-II as a potential biomarker. Our findings suggest that PIVKA-II may serve as a sensitive marker for the pathophysiology of PXE-like syndrome, and we propose that vitamin K supplementation could be beneficial in managing this disorder.