INTERACTIONS BETWEEN OLIGODENDROCYTES AND MICROGLIA

• DOI: 10.1093/brain/115.6.1611
• Publication Date: 2007-01-04T09:52:09Z
• Authors: J. P. ZAJICEK; M. WING; N. J. SCOLDING; D. A. S. COMPSTON
• Keywords: Neuroglia

Interactions between rat microglia and oligodendrocytes were examined in vitro order to characterize the stages of adherence, phagocytosis cytotoxicity against by microglia. Under resting conditions, showed minimal contact with exhibited surface staining myelin basic protein debris only; they not cytotoxic for did produce tumour necrosis factor (TNF). On activation either Γ-interferon or lipopolysaccharide interferon, these cells increased binding protein, greater living produced TNF both secreted cell bound forms. Secreted was capable killing but form this more efficiently. In presence complement, activated significant which obvious unactivated cells. These results suggest that complement are sufficient kill phagocytose oligodendrocyte-myelin complex