The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service

• DOI: 10.1093/brain/awf080
• Publication Date: 2002-07-26T22:48:15Z
• Authors: Andrew J. Hughes; Susan E. Daniel; Yoav Ben‐Shlomo; Andrew J. Lees
• Keywords: Movement Disorders

We have reviewed the clinical and pathological diagnoses of 143 cases parkinsonism seen by neurologists associated with movement disorders service at The National Hospital for Neurology Neurosurgery in London who came to neuropathological examination United Kingdom Parkinson's Disease Society Brain Research Centre, over a 10-year period between 1990 end 1999. Seventy-three (47 male, 26 female) were diagnosed as having idiopathic disease (IPD) 70 (42 28 another parkinsonian syndrome. positive predictive value diagnosis whole group was 85.3%, 122 correctly clinically diagnosed. IPD extremely high, 98.6% (72 out 73), while other syndromes it 71.4% (50 70). values multiple system atrophy (MSA) progressive supranuclear palsy (PSP) 85.7 (30 35) 80% (16 20), respectively. sensitivity 91.1%, due seven false-negative cases, 72 79 pathologically established being life. For MSA, 88.2% 34), PSP 84.2% 19). diagnostic accuracy IPD, MSA higher than most previous prospective clinicopathological series studies using retrospective application criteria. suggest broader picture previously thought acceptable. This study implies that particular expertise field may be method pattern recognition which goes beyond inherent any formal set