Motor deficits correlate with resting state motor network connectivity in patients with brain tumours

• DOI: 10.1093/brain/aws041
• Publication Date: 2012-03-10T01:19:09Z
• Authors: Marc L. Otten; Charles B. Mikell; Brett E. Youngerman; Conor Liston; Michael B. Sisti; Jeffrey N. Bruce; Scott A. Small; Guy M. McKhann
• Keywords: Premotor cortex; Supplementary motor area; Motor Control; Motor System; Motor area; Inferior parietal lobule; Superior parietal lobule

While a tumour in or abutting primary motor cortex leads to weakness, how tumours elsewhere the frontal parietal lobes affect functional connectivity weak patient is less clear. We hypothesized that diminished distributed network of centres would correlate with weakness subjects brain masses. Furthermore, we interhemispheric connections be most vulnerable subtle disruptions connectivity. used task-free magnetic resonance imaging probe networks control and patients (n = 22). Using dataset, developed method for automated detection key nodes network, including cortex, supplementary area, premotor area superior lobule, based on anatomic location hand-motor knob cortex. then calculated between subjects, as well without this information construct weighted, undirected graphs, which were compared variables interest, performance task, grooved pegboard. Strong was observed within identified all bilaterally, especially area. Reduced versus normal strength (P < 0.001). This difference driven mostly by decreases cortices 0.05) left right 0.05), other connections. In however, pegboard did not relate connectivity, but rather inversely correlated both hands 0.01). Finally, two who experienced severe following surgery their followed longitudinally, subject recovered showed reconstitution her at follow-up. The persistently reconstitute his network. Motor do involve structures associated decreased networks, particularly become weaker weaker, may strong again during recovery.