Magnetic resonance imaging pattern recognition in childhood bilateral basal ganglia disorders

• DOI: 10.1093/braincomms/fcaa178
• Publication Date: 2020-10-26T12:30:49Z
• Authors: Shekeeb S Mohammad; Rajeshwar Reddy A...; Andrew Biggin; Hugo Morales-Briceño; Robert Goetti; Belen Perez-Dueñas; Allison Gregory; Penelope Hogarth; Joanne Ng; Apostolos Papandreou; Kaustuv Bhattacharya; Shamima Rahman; Kristina Prelog; Richard I Webster; Evangeline Wassmer; Susan Hayflick; John Livingston; Manju Kurian; W Kling Chong; Russell C Dale; ; Manoj P Menezes; Sachin Gupta; Christopher Troedson; Sekhar Pillai; Esther Tantsis; Deepak Gill; Carolyn Ellaway; Simone Ardern Holmes; Jayne Antony; Kshitij Mankad; Lucinda Carr; Prab Prabhakar; Pinki Munot; Sanjay Bhate; Paul Gissen; Peter Clayton; Karin Tuschl; Louise Simmons; Yanick Crow; Troy Dalkeith
• Keywords: Movement Disorders

Bilateral basal ganglia abnormalities on MRI are observed in a wide variety of childhood disorders. pattern recognition can enable rationalization investigations and also complement clinical molecular findings, particularly confirming genomic findings enabling new gene discovery. A approach children with bilateral brain was undertaken this international multicentre cohort study. Three hundred five scans belonging to 201 34 different disorders were rated using standard radiological scoring proforma. In addition, literature review patterns these 59 additional reported abnormalities. Cluster analysis first from the study grouped them into four clusters: 1-T