Neurofilament light increases over time in severe COVID-19 and is associated with delirium

• DOI: 10.1093/braincomms/fcac195
• Publication Date: 2022-07-26T17:52:03Z
• Authors: Patrick J Smeele; Lisa Vermunt; Siebe Blok; Jan Willem Duitman; ; Michiel van Agtmael; Anne Geke Algera; Brent Appelman; Frank van Baarle; Diane Bax; Martijn Beudel; Harm Jan Bogaard; Marije Bomers; Peter Bonta; Lieuwe Bos; Michela Botta; Justin de Brabander; Godelieve de Bree; Sanne de Bruin; David TP Buis; Marianna Bugiani; Esther Bulle; Nora Chekrouni; Osoul Chouchane; Alex Cloherty; Mirjam Dijkstra; Dave A Dongelmans; Erik Duijvelaar; Romein WG Dujardin; Paul Elbers; Lucas Fleuren; Suzanne Geerlings; Theo Geijtenbeek; Armand Girbes; Bram Goorhuis; Martin P Grobusch; Florianne Hafkamp; Laura Hagens; Jorg Hamann; Vanessa Harris; Robert Hemke; Sabine M Hermans; Leo Heunks; Markus Hollmann; Janneke Horn; Joppe W Hovius; Menno D de Jong; Rutger Koning; Endry HT Lim; Niels van Mourik; Jeaninne Nellen; Esther J Nossent; Sabine Olie; Frederique Paulus; Edgar Peters; Dan AI Pina-Fuentes; Tom van der Poll; Bennedikt Preckel; Jorinde Raasveld; Tom Reijnders; Maurits CFJ de Rotte; Job R Schippers; Michiel Schinkel; Marcus J Schultz; Femke AP Schrauwen; Alex Schuurman; Jaap Schuurmans; Kim Sigaloff; Marleen A Slim; Patrick Smeele; Marry Smit; Cornelis S Stijnis; Willemke Stilma; Charlotte Teunissen; Patrick Thoral; Anissa M Tsonas; Pieter R Tuinman; Marc van der Valk; Denise Veelo; Carolien Volleman; Heder de Vries; Lonneke A Vught; Michéle van Vugt; Dorien Wouters; A H (Koos) Zwinde...; Matthijs C Brouwer; W Joost Wiersinga; Alexander PJ Vlaar; Diederik van de Beek; Esther J Nossent; Michiel A van Agt...; Leo M A Heunks; Janneke Horn; Harm Jan Bogaard; Charlotte E Teuni...
• Keywords: 2019-20 coronavirus outbreak; Pandemic

Neurological monitoring in sedated Intensive Care Unit patients is constrained by the lack of reliable blood-based biomarkers. Neurofilament light a cross-disease biomarker for neuronal damage with potential clinical applicability patients. We studied trajectory neurofilament over month diagnosed severe COVID-19 and explored its relation to outcomes pathophysiological predictors. Data were collected 31 (166 plasma samples) at Amsterdam University Medical Centre, first week after emergency department admission 297 (635 admitted Massachusetts General hospital. observed that increased non-linear fashion increases faster when compared mild-moderate cases. baseline did not predict mortality corrected age renal function. Peak levels associated longer duration delirium extubation Disease severity, as measured sequential organ failure score, was higher values, tumour necrosis factor alpha increase during admission. These data illustrate dynamics critical care setting show associations delirium, disease severity markers inflammation. Our study contributes determine utility interpretation