Interictal epileptiform discharges as a predictive biomarker for recurrence of poststroke epilepsy

• DOI: 10.1093/braincomms/fcac312
• Publication Date: 2022-11-26T12:20:05Z
• Authors: Soichiro Abe; Tomotaka Tanaka; Kazuki Fukuma; Soichiro Matsubara; Rie Motoyama; Masahiro Mizobuchi; Hajime Yoshimura; Takayuki Matsuki; Yasuhiro Manabe; Junichiro Suzuki; Hiroyuki Ishiyama; Maya Tojima; Katsuya Kobayashi; Akihiro Shimotake; Kunihiro Nishimura; Masatoshi Koga; Kazunori Toyoda; Shigeo Murayama; Riki Matsumoto; Ryosuke Takahashi; Akio Ikeda; Masafumi Ihara; ; Kazuyuki Nagatsuka; Fumiaki Nakamura; Shinya Tomari; Yoshitaka Yamaguchi; Takashi Nakamura; Naoki Makita; Yuki Nakamura; Yoshiaki Okuno; Satoshi Hosoki; Ryo Fujii; Takuro Arimizu
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Original Article

Poststroke epilepsy is a major ischaemic/haemorrhagic stroke complication. Seizure recurrence risk estimation and early therapeutic intervention are critical, given the association of poststroke with worse functional outcomes, quality life greater mortality. Several studies have reported factors for seizure recurrence; however, in epilepsy, role EEG predicting seizures remains unclear. This multicentre observational study aimed to clarify whether findings constitute factor patients epilepsy. Patients were recruited from PROgnosis POst-Stroke Epilepsy study, an cohort study. The enrolled those admitted at selected hospitals between November 2014 June 2017. All underwent during interictal period admission each hospital monitored over 1 year. Board-certified neurologists or epileptologists evaluated all findings. We investigated relationship recurrence. Among 187 (65 women median age 75 years) lead hospital, 48 (25.7%) had epileptiform discharges on EEG. During follow-up (median, 397 days; interquartile range, 337-450 days), positively correlated (hazard ratio, 3.82; 95% confidence interval, 2.09-6.97; P < 0.01). correlation remained significant even after adjusting age, sex, severity stroke, type generation antiseizure medications. detected periodic 39 (20.9%), spiky/sharp marginally associated 1.85; 0.93-3.69; = 0.08). Analysis validation comprising seven other corroborated verified that Routine may facilitate development regimens