Specialized Nutritional Support Improves Muscle Function and Maintains Physical Activity Without Affecting Chemotherapy Efficacy in a Colorectal Cancer Mouse Model

• DOI: 10.1093/cdn/nzab036_028
• Publication Date: 2021-06-07T06:33:36Z
• Authors: Liza Wijler; Danielle Raats; Sjoerd Elias; Francina Dijk; Hanil Quirindongo; Anne M May; Matthew Furber; Bram Dorresteijn; Miriam van dijk; Onno Kranenburg
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Skeletal muscle wasting and fatigue are commonly observed in cancer patients receiving chemotherapy associated with reduced treatment outcome quality of life. Nutritional support may mitigate these side effects, but potential interference efficacy could be concern. Here, we investigated the effects a ω-3-PUFA (EPA DHA), leucine-enriched, high protein (100% whey), additional vitamin D prebiotic fibers "Specific Composition" (SNC) on state-of-the-art tumor organoid models cells studied function, physical activity, systemic inflammation, mouse model aggressive colorectal (CRC). Chemotherapy consisted oxaliplatin 5-fluorouracil. Tumor formation (caliper) activity (infrared camera's) were assessed over time, while tumor-bearing mice received diet or without SNC. Ex vivo performance was determined by myography, fatty acid composition gas-chromatography, plasma cytokine levels Luminex xMAP technology. Patient-derived CRC-organoids C2C12-myotubes used to determine whether SNC affects chemotherapy-sensitivity vitro. increased contraction capacity chemotherapy-treated (P < 0.05), enriched ω-3 affecting 0.0001) compared control mice. Mice maintained after showed decreased inflammation splenomegaly. Therapeutic response unaffected nutrients, C2C12 cell viability synthesis significantly improved. The results show that specialized nutritional can maintain function during increasing viability. Therefore, strategies have value promoting tolerance. This research is part SCOPE project (Specialized nutrition improve outcomes COlorectal PatiEnts) supported Province Utrecht, Netherlands.