An update of miRNASNP database for better SNP selection by GWAS data, miRNA expression and online tools

• DOI: 10.1093/database/bav029
• Publication Date: 2015-04-15T22:31:36Z
• Authors: Jing Gong; Chunjie Liu; Wei Liu; Yuliang Wu; Zhaowu Ma; Hu Chen; An-Yuan Guo
• Keywords: 0301 basic medicine; Internet; MicroRNAs; User-Computer Interface; 03 medical and health sciences; Gene Expression Regulation; Database Update; Animals; Humans; Databases, Nucleic Acid; Polymorphism, Single Nucleotide; Genome-Wide Association Study

MicroRNAs (miRNAs) are key regulators of gene expression involved in a broad range of biological processes. MiRNASNP aims to provide single nucleotide polymorphisms (SNPs) in miRNAs and genes that may impact miRNA biogenesis and/or miRNA target binding. Advanced miRNA research provided abundant data about miRNA expression, validated targets and related phenotypic variants. In miRNASNP v2.0, we have updated our previous database with several new data and features, including: (i) expression level and expression correlation of miRNAs and target genes in different tissues, (ii) linking SNPs to the results of genome-wide association studies, (iii) integrating experimentally validated miRNA:mRNA interactions, (iv) adding multiple filters to prioritize functional SNPs. In addition, as a supplement of the database, we have set up three flexible online tools to analyse the influence of novel variants on miRNA:mRNA binding. A new nice web interface was designed for miRNASNP v2.0 allowing users to browse, search and download. We aim to maintain the miRNASNP as a solid resource for function, genetics and disease studies of miRNA-related SNPs. Database URL: http://bioinfo.life. hust.edu.cn/miRNASNP2/