An Ebola virus-centered knowledge base

• DOI: 10.1093/database/bav049
• Publication Date: 2015-06-10T19:15:22Z
• Authors: Maulik R. Kamdar; Michel Dumontier
• Keywords: Filoviridae; Ebolavirus; Ebola Hemorrhagic Fever

Ebola virus (EBOV), of the family Filoviridae viruses, is a NIAID category A, lethal human pathogen. It responsible for causing disease (EVD) that severe hemorrhagic fever and has cumulative death rate 41% in ongoing epidemic West Africa. There an ever-increasing need to consolidate make available all knowledge we possess on EBOV, even if it conflicting or incomplete. This would enable biomedical researchers understand molecular mechanisms underlying this help develop tools efficient diagnosis effective treatment. In article, present our approach development virus-centered Knowledge Base (Ebola-KB) using Linked Data Semantic Web Technologies. We retrieve aggregate from several open data sources, web services ontologies. transformed RDF, linked Bio2RDF datasets made through SPARQL 1.1 Endpoint. Ebola-KB can also be explored interactive Dashboard visualizing different perspectives integrated knowledge. showcase how competency questions, asked by domain users researching druggability formulated as Queries answered Dashboard. Database URL:http://ebola.semanticscience.org.