HEDD: the human epigenetic drug database

• DOI: 10.1093/database/baw159
• Publication Date: 2016-11-09T15:05:30Z
• Authors: Yunfeng Qi; Dadong Wang; Daying Wang; Taicheng Jin; Liping Yang; Hui Wu; Yaoyao Li; Jing Zhao; Fengping Du; Mingxia Song; Renjun Wang
• Keywords: 0303 health sciences; 03 medical and health sciences; Pharmacogenetics; Databases, Genetic; Humans; Original Article; Epigenesis, Genetic; 3. Good health

Epigenetic drugs are chemical compounds that target disordered post-translational modification of histone proteins and DNA through enzymes, the recognition these changes by adaptor proteins. drug-related experimental data such as gene expression probed high-throughput sequencing, co-crystal structure X-RAY diffraction binding constants bio-assay have become widely available. The mining integration multiple kinds can be beneficial to drug discovery repurposing. HEMD other epigenetic databases store comprehensively where users acquire segmental information drugs. However, some types datasets not provide they do support flexible queries for data. Therefore, in reference databases, we developed a relatively comprehensive database human (HEDD) focuses on storage obtained from laboratory experiments manually curated information. latest release HEDD incorporates five datasets: (i) drug, (ii) target, (iii) disease, (vi) (v) complex. In order facilitate extraction, search options were built HEDD, which allowed an unlimited condition query specific using names, diseases experiment types.