HDncRNA: a comprehensive database of non-coding RNAs associated with heart diseases

• DOI: 10.1093/database/bay067
• Publication Date: 2018-06-13T07:07:58Z
• Authors: Wen-Jing Wang; Yu-Mei Wang; Yi Hu; Qin Lin; Rou Chen; Huan Liu; Wen-Ze Cao; Hui-Fang Zhu; Chang Tong; Li Li; Lu-Ying Peng
• Keywords: Genome browser; MiRBase

Heart diseases (HDs) represent a common group of that involve the heart, number which are characterized by high morbidity and lethality. Recently, increasing evidence demonstrates diverse non-coding RNAs (ncRNAs) play critical roles in HDs. However, currently there lacks systematic investigation association between HDs ncRNAs. Here, we developed Disease-related Non-coding Database (HDncRNA), to curate HDs-ncRNA associations from 3 different sources including 1904 published articles, existing databases [the Human microRNA Disease (HMDD), miR2disease lncRNAdisease] 5 RNA-seq datasets. The with experimental validations curated these HMDD, part data lncRNAdisease were 'direct evidence'. Relationships got high-through annotated differential expressed lncRNAs defined as 'high-throughput associations'. Novel identified had least credibility 'predicted Currently, database contains 2304 for 133 6 species human, mouse, rat, pig, calf dog. also has following features: (i) A user-friendly web interface browsing searching data; (ii) visualization tool plot miRNA lncRNA locations human mouse genomes; (iii) information about neighboring genes (iv) links some mainstream miRbase, Ensemble Fantom Cat miRNAs. In summary, HDncRNA provides an excellent platform exploring related URL: http://hdncrna.cardiacdev.com