Identification of 'super-responders' to cardiac resynchronization therapy: the importance of symptom duration and left ventricular geometry

• DOI: 10.1093/europace/eup038
• Publication Date: 2009-02-24T12:58:18Z
• Authors: N. Antonio; R. Teixeira; L. Coelho; C. Lourenco; P. Monteiro; M. Ventura; J. Cristovao; L. Elvas; L. Goncalves; L. A. Providencia
• Keywords: Functional mitral regurgitation

Some patients show such an important clinical improvement and reverse remodelling after cardiac resynchronization therapy (CRT) that anatomy function approach normal. These have been called 'super-responders'. The aim of our study was to identify predictors becoming a super-responder CRT. Eighty-seven consecutive who underwent CRT were prospectively studied. Before 6 months after, echocardiographic evaluation performed. Patients with decrease in New York Heart Association functional class ≥1, two-fold or more increase left ventricular ejection fraction (LVEF) final LVEF >45%, LV end-systolic volume >15% classified as super-responders. There 12% At baseline, there no significant differences between super-responders the other patients, except for fact had significantly smaller mitral regurgitation end-diastolic diameter (LVEDD) shorter duration heart failure symptoms. Mitral jet area, LVEDD, symptoms correlated this super-response. Moreover, evolution <12 independent predictor super-response earlier phases cardiomyopathy, less altered geometry, seem greater probability