Sequence of the Structural Gene for Xanthine Dehydrogenase (rosy Locus) in Drosophila melanogaster

• DOI: 10.1093/genetics/116.1.67
• Publication Date: 2021-01-06T10:06:46Z
• Authors: Tim P Keith; Margaret A Riley; Martin Kreitman; R C Lewontin; Daniel Curtis; Geoffrey Chambers
• Keywords: Xanthine dehydrogenase; Reading frame

ABSTRACT We determined the nucleotide sequence of a 4.6-kb Eco RI fragment containing 70% rosy locus. In combination with information on 5′ sequence, gene has been sequenced in entirety. cDNAs have isolated and intron/exon boundaries determined. find an open reading frame which spans four exons would encode protein 1335 amino acids. The molecular weight encoded (xanthine dehydrogenase), based acid translation, is 146,898 daltons agrees well earlier biophysical estimates. Characteristics are discussed.