Immune Responses Associated with Chronic Fatigue Syndrome: A Case-Control Study

• DOI: 10.1093/infdis/175.1.136
• Publication Date: 2011-03-17T12:42:30Z
• Authors: A. C. Mawle; R. Nisenbaum; J. G. Dobbins; H. E. Gary; J. A. Stewart; M. Reyes; L. Steele; D. S. Schmid; W. C. Reeves
• Keywords: Adult; Male; 0301 basic medicine; Fatigue Syndrome, Chronic; Adolescent; Matched-Pair Analysis; Immunoglobulins; Receptors, Interleukin-2; Antigen-Antibody Complex; Complement System Proteins; Middle Aged; Lymphocyte Activation; Lymphocyte Subsets; 3. Good health; Killer Cells, Natural; Leukocyte Count; 03 medical and health sciences; Antigens, CD; Case-Control Studies; Cytokines; Humans; Female; Hypersensitivity, Delayed

An exploratory case-control study was conducted to assess whether the many reported differences in immune function of chronic fatigue syndrome (CFS) patients are detectable rigorously defined cases CFS. Although studies have between and controls various measures function, none these were found all studies. In this study, no white blood cell numbers; complex, complement, or serum immunoglobulin levels; delayed type hypersensitivity allergic responses; NK function; proliferative responses mitogens antigens. Marginal detected cytokine surface markers total CFS population. However, when subgrouped by disease onset (gradual sudden) how well they feeling on day testing, more pronounced seen.