HIVEP3 inhibits fate decision of CD8+ invariant NKT cells after positive selection

• DOI: 10.1093/jleuko/qiad082
• Publication Date: 2023-07-22T02:38:25Z
• Authors: Qielan Wu; Shiyu Bai; Miya Su; Yuwei Zhang; Xuran Chen; Ting Yue; Linfeng Xu; Lu Wang; Di Xie; Shuhang Li; Xiang Li; Sicheng Fu; Lili Wang; Chenxi Tian; Jun Pan; Yuanyuan Huang; Yuting Cai; Yu Wang; Fang Hu; Fengyin Li; Huimin Zhang; Li Bai

CD8+ invariant natural killer T (iNKT) cells are functionally different from other iNKT and enriched in human but not mouse. To date, their developmental pathway molecular basis for fate decision remain unclear. Here, we report enrichment of neonatal mice due to more rapid maturation kinetics than CD8- cells. Along trajectories, separate at stage 0, following 0 double-positive cells, differ HIVEP3 expression. is lowly expressed negatively controls development, whereas it highly positively development. Despite no effect on IFN-γ, inhibits granzyme B promotes interleukin-4 production Together, reveal that, as a negative regulator decision, low expression favors development helper 1-biased cytokine responses well high cytotoxicity.