CXCL17 is a proinflammatory chemokine and promotes neutrophil trafficking

• DOI: 10.1093/jleuko/qiae028
• Publication Date: 2024-02-01T08:30:23Z
• Authors: Emily Lowry; Rani C Chellappa; Brigith Penaranda; Kirti V Sawant; Maki Wakamiya; Roberto P Garofalo; Krishna Rajarathnam
• Keywords: Proinflammatory cytokine; Interleukin 8

CXCL17, a novel member of the CXC chemokine class, has been implicated in several human pathologies, but its role mediating immune response is not well understood. Characteristic features include resident macrophages orchestrating successive and structured recruitment neutrophils monocytes to insult site. Here, we show that Cxcl17 knockout (KO) mice, compared with littermate wild-type control were significantly impaired peritoneal neutrophil post-lipopolysaccharide (LPS) challenge. Further, KO mice dysregulated Cxcl1, Cxcr2, interleukin-6 levels, all which directly impact recruitment. Importantly, showed no difference monocyte post-LPS challenge or macrophage levels both unchallenged LPS-challenged mice. We conclude proinflammatory it plays an important early by promoting