Consuming a Protein and Fiber-Based Supplement Preload Promotes Weight Loss and Alters Metabolic Markers in Overweight Adults in a 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial

• DOI: 10.1093/jn/nxac038
• Publication Date: 2022-02-23T20:13:49Z
• Authors: Erin L Glynn; Stephen A Fleming; Caitlyn G Edwards; Michael J Wilson; Malkanthi Evans; Heather J Leidy
• Keywords: Preload

Higher protein and fiber diets promote weight management metabolic health. This study aimed to determine if greater loss positive changes in outcomes could be achieved with twice-daily consumption of a high-protein fiber-based multi-ingredient nutritional shake (HPF) compared an isocaloric low-protein, lower placebo (LPF). Study procedures were conducted by independent research organization under clinicaltrials.gov registration NCT03057873. Healthy overweight obese adults [n = 206; BMI (kg/m2): 27–35; 70% female] randomly assigned HPF or LPF. All participants prescribed energy-restricted diet (500 kcal/d less than energy needs) consumed (17 g protein, 6 fiber) LPF (1 3 30 min before breakfast lunch for 12 wk. Primary included body total fat percentage. Blood samples collected at days (D) 0, 28, 56, 84 secondary analyses related markers Although occurred both groups, had D84 (–3.3 kg vs. –1.8 kg, P < 0.05). Percentage decreased groups (HPF: –1.33%, LPF: –1.09%; 0.001) no differences between groups. Serum cholesterol, LDL oxidized –5.1% –8.3%, whereas adiponectin increased over time groups; these extent (all A supplement as preload positively influenced placebo. These findings suggest that specific nutrient factors (i.e., potentially including fiber, bioactive content) other calorie reduction alone influence the success weight-loss regimen. trial was registered www.clinicaltrials.gov NCT03057873,