Rheumatologic manifestations with elevated levels of IL-6, IL-17A, and IL-23 in a patient with scurvy

• DOI: 10.1093/mrcr/rxac059
• Publication Date: 2022-08-09T08:08:11Z
• Authors: Masahiro Ueki; Keita Sakamoto; Noriko Nishioka; Hiroki Ohata; Takiko Nobuta; Shunichiro Takezaki; Atsushi Manabe; Masafumi Yamada
• Keywords: Scurvy; Pathophysiology

ABSTRACT Symptomatic vitamin C deficiency, scurvy, is a relatively rare disease in developed countries, but it has been reported patients with autism spectrum disorder or developmental delay who tend to have selective diets. Patients scurvy often demonstrate musculoskeletal manifestations unknown pathophysiology. Herein, we report case of an 11-year-old boy presented iron-deficiency anaemia, systemic osteomyelitis, myositis predominantly the lower extremities, and right ventricular volume overload mild pulmonary hypertension was diagnosed scurvy. He had diet, which resulted severe deficiency. received intravenous oral supplementation, relieved his arthralgia muscle pain week. Following 4 months he demonstrated no abnormal on laboratory imaging examination recovered without sequelae. Inflammatory cytokine chemokine evaluations elevated levels interleukin (IL)-6, IL-17A, IL-23, are associated T-helper (Th) 17 cell activation. This study first suggest association between inflammation seen rheumatic patient, Th17 Further analysis supplementation may contribute new insights for comprehension treatment other inflammatory diseases, such as diseases.