The changing profile of patients with calcium nephrolithiasis and the ascendancy of overweight and obesity: a comparison of two patient series observed 25 years apart

• DOI: 10.1093/ndt/gft076
• Publication Date: 2013-04-18T03:32:13Z
• Authors: Domenico Rendina; Gianpaolo De Filippo; Francesca De Pascale; Giorgia Zampa; Riccardo Muscariello; Daniela De Palma; Renato Ippolito; Pasquale Strazzullo
• Keywords: Adult; Male; 2. Zero hunger; Oxalates; Overweight; Nephrolithiasis; Body Mass Index; Uric Acid; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Humans; Calcium; Female; Obesity; Biomarkers

Epidemiological data indicate an increasing incidence and prevalence of nephrolithiasis (NL) worldwide in the last few decades. The aim this study was to compare clinical biochemical profiles recurrent stone formers referred a Kidney Stone Centre from March 1983 June 1986 with one featured by patients seen 25 years later same geographical area, Campania, southern Italy. Idiopathic calcium made up large majority patient population both series. Those examined 2008–11 showed higher age at onset NL, overweight/obesity urinary excretion oxalate phosphate compared those 1983–86. differences variables remained significant upon accounting for age, gender, creatinine clearance body mass index (BMI), were not observed primary hyperparathyroidism enrolled periods. A greater uric acid also population. massive epidemics substantial modifications dietary habits over decades most Western countries may be factors underlying changing NL.