EXTH-30. GOLD NANOSTARS OBVIATE LIMITATIONS TO LASER INTERSTITIAL THERMAL THERAPY (LITT) AND ENHANCE THE POST-LITT IMMUNE RESPONSE

• DOI: 10.1093/neuonc/noad179.0883
• Publication Date: 2023-11-11T23:38:32Z
• Authors: Ethan Srinivasan; Yang Liu; Ren Odion; Pakawat Chongsath...; Lucas Wachsmuth; Aden Haskell-Mendoza; Ryan Edwards; Aidan Canning; Gavin Willoughby; Joseph Hinton; Stephen Norton; Christopher Lascola; Paolo Maccarini; Christopher Mariani; Tuan Vo-Dinh; Peter Fecci
• Keywords: Ex vivo; Laser Ablation; Tumor ablation

Abstract Laser interstitial thermal therapy (LITT) is a minimally-invasive technique for the treatment of intracranial tumors that uses stereotactically-guided laser and real-time magnetic resonance imaging (MRI) to monitor ablation progress. Previous applications gold nanostars (GNS) in have studied extracranial only utilized externally administered near infrared radiation cannot penetrate cranial compartment. Herein, we present novel platform employing GNS tumors. We developed non-toxic exhibit maximum photothermal effects at 1064 nm wavelength used FDA-approved clinical Neuroblate® LITT system. Monte Carlo simulations demonstrate our can accelerate focus energy distributions. Using ex vivo tumor phantom models, found GNS-infused phantoms more rapid heating improved spatial conformation energy, with neighboring material exposed lower temperatures than controls. In CT-2A glioma model, quantified accumulation radiolabeled tissue via PET/CT. As further validation tumor-selective accumulation, two-photon luminescence show selectively accumulate are retained 24 72 hours post-injection. then heterotopic model assess capacity systemically-delivered augment ablation; were able achieve higher efficient temperature ramping LITT+GNS. Finally, explored potential LITT+GNS synergize immunotherapy enhance post-ablation immune response combination resulted control immunologic memory was protective against rechallenge. These results support ability optimize by improving efficiency safety, illustrate this immunotherapy.