Invasion patterns in brain metastases of solid cancers

• DOI: 10.1093/neuonc/not112
• Publication Date: 2013-10-02T01:04:39Z
• Authors: Anna S. Berghoff; Orsolya Rajky; Frank Winkler; Rupert Bartsch; Julia Furtner; Johannes A. Hainf...; Simon L. Goodman; Michael Weller; Jens Schittenhelm; Matthias Preusser
• Keywords: Infiltration (HVAC); Parenchyma

Brain metastases are generally considered to be well demarcated from the surrounding brain parenchyma, although infiltrative growth patterns have been observed. We systemically investigated infiltration and expression of adhesion molecules in a large well-defined series autopsy cases metastases. Ninety-seven specimens 57 metastasis patients (primary tumor: 27 lung cancer, 6 breast 8 melanoma, 2 colorectal 1 kidney 13 other) were evaluated for invasion into parenchyma. Expression integrins αv; cytoplasmic β3, αvβ3, αvβ5, αvβ6, αvβ8; E N cadherin using immunohistochemistry. Three main seen: well-demarcated (29/57, 51%), vascular co-option (10/57, 18%), diffuse (18/57, 32%). There was no statistically significant association pattern with primary tumor type, most common melanoma (4/10). Invasion different same patient highly concordant (P < .001, chi-square test). Distance mass ranged 12.5 µm 450 (median 56.2 µm) not significantly between groups. Levels αvβ6 higher group than groups = .033, Kruskal-Wallis αvβ5 cells lesions previously treated stereotactic radiosurgery .034, Distinct parenchyma specific types, seem influenced by αv integrin complexes, may help guide clinical decision-making.