Genotyping low-grade gliomas among Hispanics

• DOI: 10.1093/nop/npv061
• Publication Date: 2016-01-30T02:09:04Z
• Authors: Andrés Felipe Car...; Leonardo Rojas; Beatriz Wills; José Behaine; Enrique Jiménez; Fernando Hakim; Nicolás Useche; Sonia Bermúdez; Oscar Arrieta; Juan Armando Mejía; Juan Fernando Ramón; Hernán Carranza; Carlos Vargas; Jorge Otero; Diego González; July Rodríguez; León Darío Ortiz; Hernando Cifuentes; Carmen Balaña
• Keywords: ATRX; Isocitrate dehydrogenase

Low-grade gliomas (LGGs) are classified by the World Health Organization as astrocytoma (DA), oligodendroglioma (OD), and mixed oligoastrocytoma (OA). TP53 mutation 1p19q codeletion most-commonly documented molecular abnormalities. Isocitrate dehydrogenase (IDH) 1/2 mutations frequent in LGGs; however, IDH-negative can also occur. Recent research suggests that ATRX plays a significant role gliomagenesis.We investigated p53 Olig2 protein expression, MGMT promoter methylation, codeletion, IDH, status 63 Colombian patients with LGG. The overall survival (OS) rate was estimated compared according to genotype.The most common histology DA, followed OD OA. IDH1/2 were found 57.1% MGMT+ (positive of methylation methyl-guanyl-methyl-transferase gene) 65.1% patients, while overexpression present 30.2% 44.4%, respectively, 34.9% patients. Overexpression analyzed 25 16% tested positive isocitrate negative 1p19q-codelition. median follow-up 15.8 months (95% CI, 7.6-42.0) OS 39.2 1.3-114). positively significantly affected MGMT+, surgical intervention extent, number lobes involved. Multivariate analysis confirmed OS.This is first study evaluating profile Hispanic LGG Findings prognostic relevance but do not support relevant marker. latter may be explained sample size selection bias. alterations limited DA