The Role of Social Deprivation and Cannabis Use in Explaining Variation in the Incidence of Psychotic Disorders: Findings From the EU-GEI Study

• DOI: 10.1093/schbul/sbae072
• Publication Date: 2024-05-24T18:10:57Z
• Authors: Vera Brink; Humma Andleeb; Charlotte Gayer-A...; Celso Arango; Manuel Arrojo; Domenico Berardi; Miquel Bernardo; Julio Bobes; Cristina Marta De...; Laura Ferraro; Lieuwe de Haan; Daniele La Barbera; Caterina La Cascia; Antonio Lasalvia; Pierre-Michel Llorca; Paolo Rossi Menezes; Baptiste Pignon; Julio Sanjuán; José Luis Santos; Jean-Paul Selten; Ilaria Tarricone; Andrea Tortelli; Giada Tripoli; Eva Velthorst; Bart P F Rutten; Jim van Os; Diego Quattrone; Robin M Murray; Peter B Jones; Craig Morgan; Marta Di Forti; Hannah E Jongsma; James B Kirkbride
• Keywords: Adult; Male; social inequality; Adolescent; etiology; Incidence; [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health; substance use; Psychosocial Deprivation; Middle Aged; Europe; epidemiology; etiology; social determinants of health; social inequality; substance use; Psychiatry and Mental health; Young Adult; social determinants of health, epidemiology, substance use, social inequality, etiology; Psychotic Disorders; [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health; social determinants of health; Humans; epidemiology; Female; Marijuana Use; Regular Articles

Recent findings suggest the incidence of first-episode psychotic disorders (FEP) varies according to setting-level deprivation and cannabis use, but these factors have not been investigated together. We hypothesized would be more strongly associated with variation in FEP than prevalence daily or high-potency use between settings. used data people aged 18-64 years from 14 settings EU-GEI study. estimated controls as a proxy for usage population at-risk; multiple imputations by chained equations poststratification weighting handled missing control representativeness, respectively. modeled random intercepts negative binomial regression models investigate associations controls, unemployment, owner-occupancy each setting, controlling density, age, sex, migrant/ethnic group. Lower was independently increased (adjusted rate ratio [aIRR]: 0.76, 95% CI: 0.61-0.95) non-affective psychosis (aIRR: 0.68, 0.55-0.83), after multivariable adjustment. Prevalence affective psychoses 1.53, 1.02-2.31). found no association unemployment prevalence. Sensitivity analyses supported findings. contributed variance different disorders. Public health interventions that reduce exposure harmful environmental could lower population-level burden