Shared Neurocognitive Dysfunctions in Young Offspring at Extreme Risk for Schizophrenia or Bipolar Disorder in Eastern Quebec Multigenerational Families

• DOI: 10.1093/schbul/sbn058
• Publication Date: 2008-06-13T00:34:27Z
• Authors: M. Maziade; N. Rouleau; N. Gingras; P. Boutin; M.-E. Paradis; V. Jomphe; J. Boutin; K. Letourneau; E. Gilbert; A.-A. Lefebvre; M.-C. Dore; C. Marino; M. Battaglia; C. Merette; M.-A. Roy
• Keywords: Neurocognitive

Adult patients having schizophrenia (SZ) or bipolar disorder (BP) may have in common neurocognitive deficits. Former evidence suggests impairments several neuropsychological functions young offspring at genetic risk for SZ BP. Moreover, a dose-response relation exist between the degree of familial loading and cognitive impairments. This study examines functioning high-risk (HR) parents (HRSZ) (HRBP) descending from densely affected kindreds.The sample consisted 45 (mean age 17.3 years) born to parent BP large multigenerational families Eastern Québec that are by followed up since 1989. The were administered lifetime best-estimate diagnostic procedure (Diagnostic Statistical Manual Mental Disorders, Fourth Edition [DSM-IV]) an extensive standard battery. Raw scores compared with age- gender-matched controls.The displayed differences memory executive when controls. Moderate effect sizes (Cohen d) ranging 0.65 1.25 (for IQ memory) observed. Several dysfunctions present both HRSZ HRBP, even considering DSM-IV clinical status.HRSZ HRBP shared aspects their impairment. Our data suggest extremely high these HRs contributed quantitatively increased magnitude HR subgroups, especially memory. These heightened difficulties processing information warrant preventive research.