Vitamin Bl2 Treatment for Sleep-Wake Rhythm Disorders

• DOI: 10.1093/sleep/13.1.15
• Publication Date: 2017-02-05T17:13:17Z
• Authors: M. Okawa; K. Mishima; T. Nanami; T. Shimizu; S. Iijima; Y. Hishikawa; K. Takahashi
• Keywords: Sleep

Vitamin B12 (VB12) was administered to two patients suffering for many years from different sleep-wake rhythm disorders. One patient a 15-year-old blind girl free-running (hypernychthemeral syndrome) with period of about 25 h. In spite repeated trials entrain her cycle the environmental 24-h rhythm, freerunning persisted 13 years. When she 14 old, administration VB12 per os started at daily dose 1.5 mg t.i.d. Shortly thereafter, entrained and maintained while on medication. Within 2 months withholding VB12, reappeared. The level in serum within normal range both before after treatment. other 55-year-old man delayed sleep phase syndrome since 18 age. After doses mg, his disorder improved. good therapeutic effect lasted more than 6 he