A Quantitative Comparison of Inhibitory Interneuron Size and Distribution between Mouse and Macaque V1, Using Calcium-Binding Proteins

• DOI: 10.1093/texcom/tgaa068
• Publication Date: 2020-09-24T10:45:08Z
• Authors: Roxana N Kooijmans; Wesley Sierhuis; Matthew W Self; Pieter R Roelfsema
• Keywords: Calretinin; Interneuron; Rhesus macaque

Abstract The mouse is a useful and popular model for studying of visual cortical function. To facilitate the translation results from mice to primates, it important establish extent organization equivalence between species identify possible differences. We focused on different types interneurons as defined by calcium-binding protein (CBP) expression in layers primary cortex (V1) rhesus macaque. CBPs parvalbumin (PV), calbindin (CB), calretinin (CR) provide standard, largely nonoverlapping, labeling scheme macaque, with preserved corresponding morphologies mouse, despite slightly higher overlap. Other markers, which are relevant not fluorescently tagged V1 both species, using antibodies raised against aminoacid sequences. Our data demonstrate similarities patterns interneuron classes rodents primates. However, PV CB more abundant, CR lower, laminar distribution populations differentiated. reveal an integrated view that provides basis translating suggest reconciliation previous results.