Brain Perfusion Mediates the Relationship Between miRNA Levels and Postural Control

• DOI: 10.1093/texcom/tgaa078
• Publication Date: 2020-10-26T16:00:46Z
• Authors: Yufen Chen; Amy A Herrold; Zoran Martinovich; Sumra Bari; Nicole L Vike; Anne J Blood; Alexa E Walter; Jaroslaw Harezlak; Peter H Seidenberg; Manish Bhomia; Barbara Knollmann...; Khrystyna Stetsiv; James L Reilly; Eric A Nauman; Thomas M Talavage; Linda Papa; Semyon Slobounov; Hans C Breiter
• Keywords: Putamen

Abstract Transcriptomics, regional cerebral blood flow (rCBF), and a virtual reality-based spatial motor task were integrated using mediation analysis in novel demonstration of “imaging omics.” Data collected National Collegiate Athletic Association (NCAA) Division I football athletes cleared for play before in-season training showed significant relationships 1) elevated levels miR-30d miR-92a to putamen rCBF, 2) rCBF compromised Balance scores, 3) scores microRNA (miRNA) levels. acted as consistent mediator variable (Sobel’s test P < 0.05) between abnormal miRNA scores. Given the involvement these miRNAs inflammation immune function that vascular perfusion is component inflammatory response, findings support chronic model with 11 years average exposure. systems biology measure, was necessary affect behavior.