Chromatographic profile, in silico and in vivo study of the pharmacokinetic and toxicological properties of major constituent present in kefir, the kefiran

• DOI: 10.1093/toxres/tfac032
• Publication Date: 2022-05-11T13:50:44Z
• Authors: Susy Érika de Lim...; Henrique Barros d...; Leandra Karoline ...; Lenir Cabral Correia; Maiara de Fátima ...; Mariana Pegrucci ...; Guilherme Martins...; Carlos Henrique T...; Rafael Garrett da...; Rodrigo Alves Soa...; José Carlos Tavar...; Lorane Izabel da ...
• Keywords: Lipophilicity

Kefiran is a polysaccharide present in kefir grains that have been widely explored due to its potential health benefits. The objective of this work was characterize and quantify the components ethanolic extract milk grains; study pharmacokinetic toxicological properties silico evaluate acute toxicity kefiran zebrafish. prediction performed by QikProp software. In assessment using DEREK (deductive estimate risk from existing knowledge) chromatographic, identified as major component. Results showed had low human oral absorption intestinal poor solubility profile; logP value, indicating lipophilicity MDCK Caco-2 cells permability, unable cross blood–brain barrier. did not any structural warning for toxicity. zebrafish, dose 2,000 mg/kg produced nonsignificant alterations analyzed organs. It can be said then has an acceptable degree safety use development drugs or functional foods. Further research such vivo testing confirm pharmacological currently underway.