Evaluating the Human Relevance of Chemically Induced Animal Tumors

• DOI: 10.1093/toxsci/kfh073
• Publication Date: 2004-01-27T01:14:30Z
• Authors: S. M. Cohen
• Keywords: Relevance; Mode of Action; Animal testing; Human studies; Table (database)

Defining the mode(s) of action by which chemicals induce tumors in laboratory animals has become a key to judgments about relevance such tumor data for human risk assessment. Frameworks analyzing mode information appear recent U.S. EPA and IPCS publications relating cancer This FORUM paper emphasizes that analytical frameworks depend on both qualitative quantitative evaluations relevant information: (1) presenting events animal action, (2) developing “concordance” table side-by-side comparison as defined studies with comparable from systems, (3) using analyses, well relative sensitivity exposure, make weight-of-evidence assessments. The features systematic analysis studies, based part case examples involving environmental pharmaceuticals.