Maternal Bisphenol A Diet Induces Anxiety-Like Behavior in Female Juvenile with Neuroimmune Activation

• DOI: 10.1093/toxsci/kfu085
• Publication Date: 2014-05-13T22:54:09Z
• Authors: Guangying Luo; Shaolin Wang; Zhigang Li; Ruifen Wei; Lianjie Zhang; Huanhuan Liu; Chong Wang; Ruiyan Niu; Jundong Wang
• Keywords: Proinflammatory cytokine

Maternal Bisphenol A (BPA) diet triggers anxiety in rodents, but the underlying mechanism is still unclear. Accumulating epidemiological and experimental data have demonstrated that associated with aberrant neuroimmune response. In this study, we found maternal BPA (MBD) exacerbated anxiety-like behavior female juvenile mice, molecular evidence further showed behavioral phenotype was connected to activation, such as elevated tumor necrosis factor alpha (TNF-α) interleukin (IL)-6 levels prefrontal cortex (PFC) rather than peripheral blood, which indicated response might be ascribed neuroglial activation because activated neuroglia cells could secrete proinflammatory cytokines. Subsequently, ionized calcium-binding adapter molecule (Iba)-1 a selective marker for microglia glial fibrillary acidic protein specific astrocyte were significantly increased at transcriptional translational levels, confirmed model. Therefore, conclude MBD induces excessive TNF-α IL-6 well PFC. Herein caution must taken prevent potential risks from becuase by may critical contribution subsequent growth or mental disorders.