Mechanism of Action of Lung Damage Caused by a Nanofilm Spray Product

• DOI: 10.1093/toxsci/kfu098
• Publication Date: 2014-05-27T01:12:31Z
• Authors: Søren T. Larsen; Constantin Dallot; Susan W. Larsen; Fabrice Rose; Steen S. Poulsen; Asger W. Nørgaard; Jitka S. Hansen; Jorid B. Sørli; Gunnar D. Nielsen; Camilla Foged
• Keywords: Waterproofing; Mechanism of Action

Inhalation of waterproofing spray products has on several occasions caused lung damage, which in some cases was fatal. The present study aims to elucidate the mechanism action a nanofilm product, been shown possess unusual toxic effects, including an extremely steep concentration-effect curve. product is intended for application non-absorbing flooring materials and contains perfluorosiloxane as active film-forming component. toxicological effects their underlying mechanisms this were studied using mouse inhalation model, by vitro techniques identification binding interaction. aerosolized gave rise increased airway resistance mice, evident from decreased expiratory flow rate. effect included interaction with pulmonary surfactants. More specifically, components perfluorinated siloxanes, inhibited function surfactant due non-covalent protein B, component crucial stability persistence film during respiration. used also found other market. Hence, it may be expected that these have toxicity similar here. Elucidation targets are important perform rational cost-effective studies. Thus, because system appears target products, inhibition could assessment group consumer products.