Low Dose of Bisphenol A Modulates Ovarian Cancer Gene Expression Profile and Promotes Epithelial to Mesenchymal Transition Via Canonical Wnt Pathway

• DOI: 10.1093/toxsci/kfy107
• Publication Date: 2018-04-26T06:44:11Z
• Authors: Lin Hui; Hongyi Li; Guang Lu; Zhifeng Chen; Wenjie Sun; Yu Shi; Zhiqin Fu; Bo Huang; Xinqiang Zhu; Weiguo Lu; Dajing Xia; Yihua Wu
• Keywords: KEGG; Xenoestrogen; Estrogen receptor alpha

The xenoestrogen bisphenol A (BPA) is a synthetic endocrine disrupting chemical, having the potential to increase risk of hormone-dependent ovarian cancer. Thus, deeper understanding molecular and cellular mechanisms urgently required in novel cell models cancer which express estrogen receptors. To understand possible underlying effects BPA, human adenocarcinoma SKOV3 cells were exposed BPA (10 or 100 nM) 0.1% DMSO for 24 h, then global gene expression profile was determined by high-throughput RNA sequencing. Also, enrichment analysis carried out find relevant functions pathways within differentially expressed genes significantly enriched. Transcriptomic revealed 94 differential genes. Gene Ontology Kyoto Encyclopedia Genes Genomes pathway analyses indicated that these related tumorigenesis metastasis. Further studies validate results functional annotation, increased migration invasion as well induced epithelial mesenchymal transitions A2780 cells. Accordingly, environmentally relevant-dose activated canonical Wnt signaling pathway. Our study first comprehensively analyzed on Environmentally doses modulated profile, promoted transition progress via