Evaluation of the antioxidant effects of green synthesis silver nanoparticles on brain from rats with experimental diabetes

• DOI: 10.1096/fasebj.2022.36.s1.0r795
• Publication Date: 2022-05-03T09:18:13Z
• Authors: Jenaro Lemus‐de l...; Cinthia I. Landa‐...; Mitchell Trejo‐Hu...; Donovan J. Peña‐M...; Rafael Salgado‐Ga...; Salvador Manzo‐Av...; Christian Cortés‐...; Rocío Montoya‐Pérez; Alfredo Saavedra‐...
• Keywords: Silver nanoparticle

Diabetes mellitus (DM) is a metabolic disorder of multiple etiology, the main characteristic that occurs with chronic hyperglycemia, due to insulin deficiency or resistance, combination both. One organs most affected by complications DM brain because closely related an increase in production reactive oxygen species (ROS), imbalance cellular antioxidant defense system and mitochondrial dysfunction. It has been reported highly susceptible oxidative stress. With course disease, there are various at level, such as development Alzheimer's, cognitive decline, alterations neurotransmission, neuroinflammation, apoptosis, necrosis, among others. On other hand, traditional medicine emerged alternative treatment diseases, including DM; one plants used treat diabetes Eryngium carlinae, which already experimentally shown have hypoglycemic, hypolipidemic properties, can be antidiabetic treatment. Moreover, new strategies sought ensure rapid effective administration drugs recent years. these using green synthetic nanoparticles, combine use plant extracts metallic nanoparticles more significant biological effect. The objective this work was compare effect extract its silver (AgNP) on glucose levels function. AgNP obtained from aqueous E. carlinae characterized UV-Vis SEM. 36 male Wistar rats without experimental (STZ 45 mg/Kg weight) were divided into 6 groups n = treated not dose 30 weight extract-AgNP for days. diabetic group showed triglycerides blood, well ROS lipoperoxidation mitochondria. Also, decrease SODmt, GPx complexes I, II III activities compared control group. Administration treatments decreased lipoperoxidation, they also restored CTE group, only significantly blood triglyceride levels, Our results suggest both reverse production, dysfunction brain, (extract-AgNP) lowers DM.